What are the benefits of characterizing pharmaceuticals with thermal analysis?

Thermal analysis is a well-established method for the characterization of active pharmaceutical ingredients, excipients or formulations and is listed in various pharmacopeias. Differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) are ideally suited to provide information about

- the melting temperature of crystalline substances
- polymorphic forms
- purity
- the glass transition of amorphous materials
- thermal stability of chemicals
- evaporation phenomena
- pyrolysis behavior

Which meaningful conclusions can be drawn from such measurements regarding processability, compatibility between the components in a physical mixture, shelf life, etc.? Selected best-practice examples will give you an overview of the applicability of DSC and TGA in the pharmaceutical field.

March 12, 2019

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